SUBSTITUTED ISOCHROMAN COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS, CANCER AND OTHER DISEASES

摘要

The invention relates to novel heterocyclic compounds having the structure illustrated by Formula (1) wherein the Ar1 radicals are substituted isochroman radicals, the Ar2 radicals are aryl or heteroaryl radicals; and HAr is a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one radical. The compounds of Formula (1) can have biological activity for advantageously regulating carbohydrate metabolism, including serum glucose level, and lipid metabolism, and can be useful for the treatment of hyperlipidernia and/or hypercholesterolemia, and Type 11 diabetes. The compounds of Formula (1) can also have utility in the treatment of diseases of uncontrolled proliferation, including cancer.