| 摘要 |
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from : (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm. |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE, ACTING THROUGH LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER IN SHREVEPORT;UNIVERSITY OF ALABAMA RESEARCH FOUNDATION;LOMA LINDA UNIVERSITY;WAKE FOREST UNIVERSITY;GLADWIN, MARK, T.;SCHECHTER, ALAN, N.;LEFER, DAVID, J.;PATEL, RAKESH, P.;HUNTER, CHRISTIAN, J.;POWER, GORDON, G.;KIM-SHAPIRO, DANIEL, B.;PLUTA, RYSZARD;OLDFIELD, EDWARD, H. |
发明人 |
GLADWIN, MARK, T.;SCHECHTER, ALAN, N.;LEFER, DAVID, J.;PATEL, RAKESH, P.;HUNTER, CHRISTIAN, J.;POWER, GORDON, G.;KIM-SHAPIRO, DANIEL, B.;PLUTA, RYSZARD;OLDFIELD, EDWARD, H. |
