GENOMICALLY MODIFIED CELL NEUTRALIZED TO SERUM-FREE SYSTEM

摘要

Attempts have been made to develop host cells capable of producing glycoprotein compositions such as antibody compositions useful in drug discovery. It is intended to provide a cell having been neutralized to a serum-free medium and carrying a knockout genome gene of an enzyme which participates in a sugar chain modification whereby fucose is attached via an alpha-bond at the 1-position to the 6-position of N-acetylglucosamine at the reducing end of an N-glycoside-binding complex sugar chain; and a process for producing a glycoprotein composition with the use of this cell.