发明名称 |
THROMBOPOIETIN PROTEINS WITH IMPROVED PROPERTIES |
摘要 |
The invention concerns human thrombopoietin and in particular modified forms of thrombopoietin (TPO) with improved properties. The improved proteins contain amino acid substitutions at specific positions within the TPO molecule. The invention provides modified TPO molecules, preferably fusion proteins comprising immunoglobulin constant regions and modified human TPO, with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans. |
申请公布号 |
WO2005000891(A3) |
申请公布日期 |
2005.04.21 |
申请号 |
WO2004EP06887 |
申请日期 |
2004.06.25 |
申请人 |
MERCK PATENT GMBH;BAKER, MATTHEW;WATKINS, JOHN |
发明人 |
BAKER, MATTHEW;WATKINS, JOHN |
分类号 |
A61K38/00;A61K39/00;C07K14/52 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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