Angiogenic tri- or tetrapeptides derived from AcSDKP

摘要

The present invention relates to the use of a compound of formula I: in which, A₁ is the radical corresponding to D- or L-Ser, A₂ is the radical corresponding to D- or L-Asp or Glu, A₃ is the radical corresponding to D- or L-Lys, Arg or Gm, A₄ is the radical corresponding to D- or L-Pro, R₁ and R₂ are chosen, independently, from H, C₁-C₁₂-alkyl which may or may not be substituted, C₇-C₂₀-arylalkyl which may or may not be substituted, R₄CO or R₄COO, R₄ being C₁-C₁₂-alkyl which may or may not be substituted, or C₇-C₂₀-arylalkyl which may or may not be substituted; among the substitutions, mention should be made of OH, NH₂ or COOH, X₁ and X₂ are peptide or pseudopeptide bonds, X₃ is CO or CH₂ and R₃ is OH, NH₂, C₁-C₁-alkoxy or NH-X₄-CH₂-Z, X₄ is a normal or branched C₁-C₁₂ hydrocarbon, and Z is H, OH, CO₂H or CONH₂, or the corresponding tripeptides comprising the radicals A₁, A₂, A₃, and also the pharmacautically acceptable salts, for the preparation of a medicament for treating pathologies which may benefit from stimulation of angiogenesis.