发明名称 |
IMPROVED ADENOVIRUS AND METHODS OF USE THEREOF |
摘要 |
A recombinant adenovirus and a method for producing the virus are provided which utilize a recombinant shuttle vector comprising adenovirus DNA sequence for the 5' and 3' cis-elements necessary for replication and virion encapsidation in the absence of sequence encoding viral genes and a selected minigene linked thereto, and a helper adenovirus comprising sufficient adenovirus gene sequences necessary for a productive viral infection. Desirably the helper gene is crippled by modifications to its 5' packaging sequences, which facilitates purification of the viral particle from the helper virus. |
申请公布号 |
EP0787200(B1) |
申请公布日期 |
2005.04.20 |
申请号 |
EP19950942839 |
申请日期 |
1995.10.27 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
WILSON, James, M.;FISHER, Krishna, J.;CHEN, Shu-Jen;WEITZMAN, Matthew |
分类号 |
C12N15/09;A61K35/76;A61K48/00;C12N7/00;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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