HUMAN PROSTATE CANCER CELL FACTOR(S) THAT INDUCE STEM CELL COMMITMENT AND OSTEOGENESIS
摘要
Human prostate cancer (CaP) cells secrete biological activities that recruit cells to differentiate into the osteoblast lineage. Conditioned medium (CM) produced by metastatic human CaP cells (DuCaP and VCaP) induced commitment and differentiation of mesenchymal stem cells (MSC) into osteoblasts. CaP-CM induces cellular condensation into tissue-like aggregates. In turn, these tissue-like aggregates secrete and mineralize a bone matrix, forming bone outside the body (ex vivo). Thus, conditioned media and/or proteins isolated therefrom may be used to facilitate bone formation in fracture repair and bone diseases.
申请公布号
WO2005032344(A2)
申请公布日期
2005.04.14
申请号
WO2004US32096
申请日期
2004.10.01
申请人
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;HALL, CHRISTOPHER, L.;FRIEDMAN, MICHAEL;LONG, MICHAEL, W.
发明人
HALL, CHRISTOPHER, L.;FRIEDMAN, MICHAEL;LONG, MICHAEL, W.