METHODS OF INHIBITING VASCULAR PERMEABILITY AND APOPTOSIS
摘要
Agonist of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated froms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial sphingosine-1-phosphate receptor agonists are employed in methods of treating a mammal for vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels. The sphingosine-1-phosphate receptor agonists can be used for the manufacture of a medicament for treating vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels.
申请公布号
WO2005002559(A3)
申请公布日期
2005.04.14
申请号
WO2004US19420
申请日期
2004.06.18
申请人
UNIVERSITY OF CONNECTICUT;HLA, TIMOTHY;SANCHEZ, TERESA;PAIK, JI-HYE;CLAFFEY, KEVIN, P.
发明人
HLA, TIMOTHY;SANCHEZ, TERESA;PAIK, JI-HYE;CLAFFEY, KEVIN, P.