| 摘要 |
Compositions and methods are provided for modulating the survival and maturation of male and female mammalian germ cells. Compounds that interfere with the binding of INSL3 to its receptor, LGR8, are administered to an individual to prevent oocyte maturation, thereby acting as a contraceptive. INSL3 or INLS3 agonists are administered to an individual, or to cells in vitro, to enhance oocyte maturation, either for infertility treatment or for contraception. Compounds that interfere with the binding of INSL3 to its receptor are administered to an individual to enhance male germ cell apoptosis, thereby acting as a contraceptive. INSL3 or INLS3 agonists are administered to an individual, or to cells in vitro, to enhance sperm cell survival. LGR8 and INSL3 are useul separately or in combination in the screening and design of agonists and antagonists for use in the methods of the invention.
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