HETEROCYCLIC COMPOUNDS

摘要

1H-Benzoimidazol-2-YL)-(Piperazinyl)- Methanone derivatives of formula (I) and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders (I) wherein B and B1 are C or up to one of B and B 1 maybe N; Y is O, Sor NR2, where R2 is H or C1-4alkyl; Zis O or S; R8 is H and R 9 is (a), where R10 Is H or C1-4alkyl, or R 8 and R9 are taken together with their N of attachment to form (b); n is 1 or 2; m is 1 or 2; n + m is 2 or 3; other substituents as defined in claim 1.