发明名称 |
Method for determining susceptibility to heart disease by screening polymorphisms in the vitamin D receptor gene |
摘要 |
The present invention relates to prognostic method and means for determining susceptibility to heart disease in a subject by screening for polymorphisms in the Vitamin D receptor gene. In particular, the present invention provides a method for determining susceptibility to heart disease, the method comprising analysing the genetic material of a subject to determine which of the B/b, A/a or T/t alleles of the restriction enzyme sites BsmI, ApaI and TaqI respectively are present. Specific combinations of alleles represent a haplotype which is associated with susceptibility to heart disease.
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申请公布号 |
US2005074786(A1) |
申请公布日期 |
2005.04.07 |
申请号 |
US20030703715 |
申请日期 |
2003.11.07 |
申请人 |
ERASMUS UNIVERSITEIT ROTTERDAM |
发明人 |
UITTERLINDEN ANDREAS GERARDUS;VAN LEEUWEN JOHANNES PETRUS THOMAS MARIA;PIETER POLS HUIBERT ADRIAAN |
分类号 |
G01N33/50;C12N15/09;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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