摘要 |
Disclosed are compositions and methods related to NEDD4L, a ubiquitin ligase, and hypertension as well as viral budding. A systematic search for genetic polymorphism was conducted by resequencing exon and intron boundaries in human genomic DNA. Isoforms encoding a Ca <2+>-dependent lipid binding C2 domain at the N-terminus of NEDD4L were identified. Additional isoforms lacing the C<a+ ->dependent lipid binding C2 domain were also identified. A common polymorphism was identified, Variant 13, with either G (70%) or A (30%) as the last nucleotide of exon 1, which effects splice site function and formation of the C<a+>-dependent lipid binding C2 domain. Identified isoforms are present in both kidney and adrenal samples. |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION;UNIVERSITY OF MINNESOTA;WEISS, ROBERT, B.;LALOUEL, JEAN-MARC;PANKOW, JAMES;DUNN, DIANE, M. |
发明人 |
WEISS, ROBERT, B.;LALOUEL, JEAN-MARC;PANKOW, JAMES;DUNN, DIANE, M. |