发明名称 |
Process for preparing an (S)-4-amino-5-chloro-2-methoxy-N-(1-(1- (2-tetrahydrofurylcarbonyl)-4-piperidinylmethyl(-4- piperidinyl(benzamide, pharmaceutical composition which comprises derivative thereof and intermediate product thereof |
摘要 |
<p>The compound (S)-4-Amino-5-chloro-2-methoxy-N-Ä1-Ä1-(2-tetrahydrofuryl-carbonyl)-4-piperidinylmethylÜ-4-piperidinylÜbenzamide of the following formula (I): <CHEM> or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, is useful as a gastrointestinal motility enhancer or a gastrointestinal prokinetic agent, which shows a potent affinity for 5-HT4 receptor, and shows few effects on the heart, and further shows few side effects on the central nervous system based on the dopamine D2 receptor. A process for preparing the compound, a pharmaceutical composition containing it and an intermediate therefor are also described.</p> |
申请公布号 |
SK50192004(A3) |
申请公布日期 |
2005.04.01 |
申请号 |
SK20040005019 |
申请日期 |
2003.05.15 |
申请人 |
DAINIPPON PHARMACEUTICAL CO., LTD. |
发明人 |
KATO SHIRO;YAMAZAKI HIROSHI;HIROKAWA YOSHIMI;KAN YOKO;YOSHIDA NAOYUKI;MORIKAGE KAZUO;MORIKAGE YUKIKO |
分类号 |
C07D405/14;A61K31/4525;A61K31/4545;A61P1/00;A61P1/04;A61P1/14;A61P43/00;(IPC1-7):C07D405/14;A61K31/454 |
主分类号 |
C07D405/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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