HISTONE MODIFICATIONS AS BINARY SWITCHES CONTROLLING GENE EXPRESSION
摘要
The present invention relates to a method of modulating a chromatin binding protein or complex which binds to a functional group on an amino acid of a histone. This method involves phosphorylating or dephosphorylating a serine or threonine on the histone proximate to the amino acid under conditions effective to modulate the chromatin binding protein or complex. This method is particularly useful in treating or preventing cancer in a subject. In addition, the histone comprising a serine or threonine proximate to an amino acid capable of binding to a functional group can be used to screen for compounds which prevent or treat cancer. Also disclosed is an antibody or binding portion thereof raised against a binary switch on a histone comprising a phosphorylated serine or threonine proximate to an amino acid bound to a functional group and its use in detecting a condition mediated by that switch.
申请公布号
WO2005028620(A2)
申请公布日期
2005.03.31
申请号
WO2004US30161
申请日期
2004.09.15
申请人
THE ROCKEFELLER UNIVERSITY;ALLIS, DAVID, C.;FISCHLE, WOLFGANG;DORMANN, HOLGER