发明名称 |
14-3-3 BINDING MOLECULES AS SENSITIZERS FOR ANTICANCER THERAPIES |
摘要 |
Methods are provided for enhancing the death of a neaplastic cell comprising the administration of a therapeutically effective concentration of a 14-3-3 antagonist and at least one antineoplastic therapeutic agent. The methods of the invention find use in improving the clinical outcome of a mammal having a neoplastic disorder and comprises administration to a mammal in need thereof at least one antineoplastic therapeutic agent in combination with a 14-3-3 antagonist. Further provided are pharmaceutical compositions having a therapeutically effective amount of a 14-3-3 antagonist and an antineoplastic therapeutic agent. Also provided are methods for identifying agents that selectively inhibit an interaction between a 14-3-3 polypeptide and a 14-3-3 ligand.
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申请公布号 |
WO02067968(A9) |
申请公布日期 |
2005.03.31 |
申请号 |
WO2002US04948 |
申请日期 |
2002.02.20 |
申请人 |
EMORY UNIVERSITY;FU, HAIAN;MASTERS, SHANE, C. |
发明人 |
FU, HAIAN;MASTERS, SHANE, C. |
分类号 |
A61K31/704;A61K31/7048;A61K31/7072;A61K38/00;A61K38/10;A61K38/16;A61K38/17;A61K45/06;A61P35/00;C07K14/00;(IPC1-7):A61K38/10 |
主分类号 |
A61K31/704 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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