| 摘要 |
Products and methods for treating fibrosis, liver cirrhosis and cancer, and for altering or modulating the expression of genes regulated by transforming growth factor-beta (TGF-beta) are provided. Nucleic acid molecules comprising TGF-response elements have a high affinity for transcription factors modulated by TGF-beta. In one embodiment, nucleic acid molecules comprising TGF-beta response elements can be used as decoys to alter the expression of genes regulated by TGF-beta (e.g., proalpha1(I) collagen) and treat a variety of conditions related to aberrant expression of TGF-beta regulated genes (e.g., fibrosis, liver cirrhosis, tumors, cancers).
|
