发明名称 IMIDAZOQUINOLINES, PHARMACEUTICAL PREPARATION AND METHOD FOR INDUCTION OF CYTOKINE BIOSYNTHESIS BASED ON THEREOF
摘要 FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to new imidazoquinolines of the formula (1): wherein R, R1, R2 and n have values given in the description. Compounds elicit effect of immunomodulating agents inducing biosynthesis of cytokines in animals in treatment of different pathologies, among them viral and neoplastic diseases. Also, invention relates to a pharmaceutical preparation used for inducing interferon-alpha or tumor necrosis alpha-factor, to a method for inducing biosynthesis of cytokines in animals and to methods for treatment of viral diseases and neoplasm pathologies in animals. Invention provides preparing new biologically active compounds. ^ EFFECT: improved inducing method, valuable properties of compounds and pharmaceutical preparation. ^ 23 cl, 10 tbl, 231 ex
申请公布号 RU2248975(C2) 申请公布日期 2005.03.27
申请号 RU20010132139 申请日期 2000.06.08
申请人 发明人 KRUKS STEFEN L.;LINDSTROM KAJL DZH.;MERRILL BRAJON A.;RAJS MAJKL DZH.
分类号 A61K9/00;A61K31/437;A61K31/4745;A61K31/496;A61K31/541;A61K45/06;A61P31/12;A61P35/00;A61P37/02;C07D471/04 主分类号 A61K9/00
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