CRF ANTAGONISTS AND HETEROBICYCLIC COMPOUNDS

摘要

CRF antagonists containing as the active ingredient compounds represented by the general formula (I): (I) wherein A is an optionally substituted 5- or 6- membered monocycle; B is a 5- to 7-membered monocyclic unsaturated heterocyc le which may additionally contain one or two heteroatoms and which may be additionally substituted; W1 and W2 are each carbon or nitrogen; Z is NR3, oxygen, optionally oxidized sulfur, or CR4R5; R1 is optionally substituted, alkyl, alkenyl, or alkynyl, optionally protected amino, optionally protected hydroxyl, optionally protected SH, S(O)nR6, COR7, or an optionally substitut ed cyclic group; and R2 is an unsaturated cyclic group which may be substituted .