发明名称 |
Antibody fragment-polymer conjugates and humanized anti-IL-8 monoclonal antibodies |
摘要 |
Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.
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申请公布号 |
US6870033(B1) |
申请公布日期 |
2005.03.22 |
申请号 |
US19990355014 |
申请日期 |
1999.09.13 |
申请人 |
GENENTECH, INC. |
发明人 |
HSEI VANESSA;KOUMENIS IPHIGENIA;LEONG STEVEN R.;PRESTA LEONARD G.;SHAHROKH ZAHRA;ZAPATA GERARADO A. |
分类号 |
C12N15/09;A61K38/00;A61K47/48;A61P37/00;C07K16/24;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;(IPC1-7):C07K16/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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