| 摘要 |
The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-hum an primates which may be associated with a physiological condition, such as enhanced resistance to AIDS infection. The invention also provides methods f or identifying evolutionarily significant polynucleotides with mutations that a re correlated with susceptibility to diseases, such as ICAM 1. The methods empl oy comparison of human and non-human primate sequences using statistical method s. Sequences thus identified may be useful as host therapeutic targets and/or i n screening assays.
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