MEDICAMENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS OR DIABETES

摘要

Novel compounds and methods are provided for the treatment of human neurodegenerative diseases, diabetes, mental conditions, inflammatory diseases, strokes and cancers. The compounds are small molecule inhibitors of glycogen synthease kinase-3 proteins. GSK-3 kinase protein/small molecule inhibitor compound adducts are also described wherein the compounds are bonded to the kinase proteins at the region of a protein switch control pocket in order to alter the conformation and/or protein activity of the kinases.