DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN-COUPLED RECEPTOR ADENOSINE A2B (ADORA2B)

摘要

The invention provides a human ADORA2B which is associated with the cardiovascular disorders, dermatological disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, cancer disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, cancer disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of ADORA2B as well as pharmaceutical compositions comprising such compounds.