发明名称 |
Biosynthetic binding protein for cancer marker |
摘要 |
Disclosed is a single-chain Fv (sFv) polypeptide defining a binding site which exhibits the immunological binding properties of an immunoglobulin molecule which binds c-erbB-2 or a c-erbB-2-related tumor antigen, the sFv includes at least two polypeptide domains connected by a polypeptide linker spanning the distance between the C-terminus of one domain and the N-terminus of the other, the amino acid sequence of each of the polypeptide domains includes a set of complementarity determining regions (CDRs) interposed between a set of framework regions (FRs), the CDRs conferring immunological binding to the c-erbB-2 or c-erbB-2-related tumor antigen.
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申请公布号 |
EP1514934(A2) |
申请公布日期 |
2005.03.16 |
申请号 |
EP20040078206 |
申请日期 |
1993.02.05 |
申请人 |
CHIRON CORPORATION |
发明人 |
RING, DAVID B.;HOUSTON, L. L. |
分类号 |
C12N15/09;A61K39/395;A61K49/00;A61K51/00;A61K51/08;A61P35/00;C07H21/04;C07K16/22;C07K16/28;C07K16/30;C07K16/32;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12N15/62;C12N15/66;C12P21/02;C12P21/08;C12R1/19;(IPC1-7):C12N15/13 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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