| 发明名称 |
PRODRUGS OF THROMBIN INHIBITORS |
| 摘要 |
There is provided compounds of formula I, R<1>O(O)C-CH2-(R)Cgl-Aze-Pab-R<2> wherein R<1> and R<2> have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants. |
| 申请公布号 |
EP0869966(B1) |
申请公布日期 |
2005.03.16 |
| 申请号 |
EP19960943446 |
申请日期 |
1996.12.17 |
| 申请人 |
ASTRAZENECA AB |
发明人 |
ANTONSSON, THOMAS;GUSTAFSSON, DAVID;HOFFMANN, KURT-JUERGEN;NYSTROEM, JAN-ERIK;SOERENSEN, HENRIK;SELLEN, MIKAEL |
| 分类号 |
A61K38/55;A61K;A61K31/00;A61K38/00;A61K38/05;A61K38/06;A61P7/00;A61P7/02;A61P9/10;A61P43/00;C07D;C07D487/04;C07D491/04;C07D495/04;C07K;C07K1/02;C07K5/00;C07K5/02;C07K5/06;C07K5/065;C12N9/99 |
主分类号 |
A61K38/55 |
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