| 摘要 |
A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereofWhereinR<1 >and R<2 >are independently H or C1-3 alkyl or R<1 >and R<2 >which are bonded to the same carbon atom may together with the carbon atom to which they are bonded form a 3-5 membered cycloalkyl ring;X1 represents O or S;Each R<3>, R<4>, R<8 >and R<9 >independently represents H, halogen, -CH3 and -OCH3;R<5 >represents H or C1-6 alkyl or R<4 >and R<5 >together form a 3-6 membered cycloalkyl ring.X2 represents NH, NCH3 or O;One of Y and Z is N, and the other is O or S;R<6 >represents phenyl or pyridyl (wherein the N is in position 2 or 3) and is optionally substituted by one or more halogen, CF3, C1-6 straight or branched alkyl (optionally substituted by halogen), with the provision that when R<6 >is pyridyl, the N is unsubstituted.R<7 >represents C1-6alkyl, (optionally substituted by one or more halogens), -C0-8alkyl-5 membered heteroaryl, C0-6alkyl-(O)n-phenyl, wherein n is 0 or 1, with the proviso that when R<1 >and R<2 >are methyl, R<8 >and R<9>are H, R<5 >is H, then R<7 >cannot be CH3 or CF3.
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