OXAZOLE DERIVATIVES AND THEIR USE AS INSULIN SENSITIZERS

摘要

and pharmaceutically acceptable salts and esters thereof, wherein R1 is aryl; R2 is hydrogen, alkyl or cycloalkyl; R3 is hydrogen, alkyl, aralkyl, aryl, alkylcarbonyl, arylcarbonyl, alkyl-S(O) 2- or aryl-S(O)2- ; R4 is aralkyl; R5, R6, R7 and R8 are independently selected from hydrogen, alkyl or cycloalkyl; and n is 1,2,3,4 or 5, are useful as insulin sensititers, particularly PPAR activators.