PROCESS FOR PREPARING A MEDICAMENT

摘要

The present invention provides a process for preparing a particulate medicament that has greater homogeneity and a lower adhesion between the particles of the active ingredient and the carrier. The process comprises th e steps of: (a) combining a pharmaceutically active ingredient in the form of an agglomerate of primary particles having an agglomerate particle size such th at the agglomerate is capable of passing through a sieve having a mesh of 50-30 00 ~m with a pharmaceutically acceptable particulate carrier, and (b) mixing th e resultant material in a mixer to break up the agglomerate into primary particles dispersed in the pharmaceutically acceptable particulate carrier such that 90% or more of the pharmaceutically active ingredient exists as primary particles having a particle size of 50 ~m or less.