2,4-DIAMINO-5-[5'-SUBSTITUTED-BENZYL] PYRIMIDINES AND 2,4-DIAMINO-6-[5'-SUBSTITUTED-BENZYL] QUINAZOLINES

摘要

The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors. More particularly, the present invention relates to dihydrofolate reductase inhibitors having a substituted aromatic group and a heteroaromatic group linked by a methylene group wherein at least one of the aromatic group substituents is a lipophilic residue comprising at least one acidic functional group.