摘要 |
Comopudns represented by formula (I) wherein R is C1-6cycloalkylalkyl; or C3-6 alkenyl; R' is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence of µ agonists. |
申请人 |
SOUTHERN RESEARCH INSTITUTE;NATIONAL INSTITUTE ON DRUG ABUSE;UNIVERSITY OF NEW ENGLAND COLLEGE OF OSTEOPATHIC MEDICINE;COLLEGE OF MEDICINE - THE UNIVERSITY OF ARIZONA HEALTH SCIENCES CENTER;ANANTHAN, SUBRAMANIAM;ROTHMAN, RICHARD, B.;BILSKY, EDWARD, J.;PORRECA, FRANK |
发明人 |
ANANTHAN, SUBRAMANIAM;ROTHMAN, RICHARD, B.;BILSKY, EDWARD, J.;PORRECA, FRANK |