发明名称 |
Wasp venom allergens with reduced IgE-reactivity |
摘要 |
<p>Recombinant insect allergens (I) having reduced immunoglobulin E (IgE) reactivity and allergenicity, are new. Independent claims are also included for the following: (1) producing essentially pure recombinant insect venom allergens (Ia) though preparation as inclusion bodies (IB), in bacterial cells; denaturing IB, then conversion to soluble, monomeric form with different folding conformations by dialysis; (2) recombinant wasp venom allergens (Ib) produced by method (1); and (3) use of recombinant (I) with normal allergenicity and IgE reactivity for in vitro diagnosis of insect sting allergies. ACTIVITY : Anti-allergic; immunomodulatory. MECHANISM OF ACTION : None given in the source material.</p> |
申请公布号 |
EP1512694(A1) |
申请公布日期 |
2005.03.09 |
申请号 |
EP20040027711 |
申请日期 |
2000.11.27 |
申请人 |
MERCK PATENT GMBH |
发明人 |
FIEBIG, HELMUT, PROF. DR. HABIL. NAT.;SUCK, ROLAND, DR.;CROMWELL, OLIVER, DR. |
分类号 |
G01N33/53;A61K39/00;A61K39/35;A61P37/08;C07K14/00;C07K14/435;C12N15/09;C12P21/00;C12P21/02;(IPC1-7):C07K14/435;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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