发明名称 |
Methods of identifying genetic risk for and evaluating treatment of alzheimer's disease by determining cyp46 genotype |
摘要 |
Based on the unexpected identification of a CYP46 gene polymorphism as a novel genetic risk factor that links cholesterol metabolism to Alzheimer's disease, the present invention provides a method of diagnosing or prognosticating Alzheimer's disease, or determining the propensity or predisposition of a subject to develop Alzheimer's disease. The method comprises detecting the presence or absence of a variation in the CYP46 gene which encodes the enzyme cholesterol 24-hydroxylase.
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申请公布号 |
US2005048492(A1) |
申请公布日期 |
2005.03.03 |
申请号 |
US20040495261 |
申请日期 |
2004.11.02 |
申请人 |
PAPASSOTIROPOULOS ANDREAS;STREFFER JOHANNES R.;NITSCH ROGER M.;HOCK CHRISTOPH |
发明人 |
PAPASSOTIROPOULOS ANDREAS;STREFFER JOHANNES R.;NITSCH ROGER M.;HOCK CHRISTOPH |
分类号 |
C12Q1/68;G01N33/573;G01N33/68;G01N33/92;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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