发明名称 |
IN VIVO TARGETING OF DENDRITIC CELLS |
摘要 |
<p>The invention provides a composition for modulating immunity by the in vivo targeting of an antigen to dendritic cells. The composition comprises: a preparation of antigen-containing membrane vesicles or antigen-containing liposomes which have on their surfaces a plurality of metal chelating groups; and, a ligand for a receptor on the dendritic cells, the ligand being linked to a metal chelating group via a metal affinity tag on the ligand. The composition further includes an immunomodulatory factor. A process for preparing the composition is also provided. The invention further provides a method of modulating an immune disorder, and methods of treating tumours and infections.</p> |
申请公布号 |
WO2005018610(A1) |
申请公布日期 |
2005.03.03 |
申请号 |
WO2004AU01125 |
申请日期 |
2004.08.23 |
申请人 |
LIPOTEK PTY LTD;ALTIN, JOSEPH;PARISH, CHRISTOPHER, RICHARD |
发明人 |
ALTIN, JOSEPH;PARISH, CHRISTOPHER, RICHARD |
分类号 |
A61K9/127;A61K31/4172;A61K39/00;A61K39/39;A61P35/00;A61P37/02;(IPC1-7):A61K9/127;A61K31/417 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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