发明名称 |
CLAUDINS' UNDEREXPRESSION AS MARKERS OF TUMOR METASTASIS |
摘要 |
A method for treating cancer in a mammal comprised of administering a therapeutically effective amount of an agent that induces the expression of one or more claudins within a cancerous cell. Preferably the claudin is claudin-3, claudin-4 aor claudin-9. In a preferred method, a nucleic acid that encodes a claudin is administered to the mammal under conditions wherein the nucleic acid is transfected into the cancerous cell and the claudin is produced in the cell. Also disclosed is a method for diagnosing cancer comprising determining the presence of a claudin 3, 4 or 9 in a cell that normally expresses the protein. If the cell does not express the claudin, then it is cancerous. |
申请公布号 |
WO2004098647(A3) |
申请公布日期 |
2005.03.03 |
申请号 |
WO2004US13436 |
申请日期 |
2004.04.30 |
申请人 |
NASTECH PHARMACEUTICAL COMPANY INC.;QUAY, STEVEN, C.;CUI, KUNYUAN |
发明人 |
QUAY, STEVEN, C.;CUI, KUNYUAN |
分类号 |
A61K;A61K48/00;C12N15/86;C12Q1/68;G01N33/574 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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