BIOLOGICALLY ACTIVE PEPTIDE DERIVED FROM FUNCTIONAL DOMAIN OF BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN AND ITS USE

摘要

PROBLEM TO BE SOLVED: To provide a new substance which can be used as a bactericide and an endotoxin neutralizer and is used for heparin neutralization and heparin inhibition in (normal or pathological) angiogenesis; and use thereof. SOLUTION: The new substance is a peptide having BPI biological activities and contains an amino acid sequence derived from a functional domain ranging from about 17th position to about 45th position (from about 65th position to about 99th position or from about 142nd position to about 169th position) of the amino acid sequence of a human bactericidal/permeability-increasing (BPI) protein or a subsequence thereof, and variants of the sequence or subsequence thereof. COPYRIGHT: (C)2005,JPO&NCIPI