Compositions and methods for tumor-targeted delivery of effector molecules

摘要

An attenuated tumor-targeted bacteria, preferably Salmonella, comprising one or more nucleic acid molecules encoding one or more primary effector molecules e.g. a TNF family member, anti-angiogenic factor, bacteriocin family member, tumor inhibitory enzyme, hemolysin, verotoxin, CNF1, CNF2 or PMT, and one or more secondary effector molecules e.g. an immunomodulating agent, an anti-tumor protein, a prodrug converting enzyme, an antisense molecule, a ribozyme, bacteriocin release factor or an antigen, operably linked to one or more promoters, wherein the attenuated tumor-targeted bacteria is a facultative anaerobe and the effector is not an endogenous gene; a pharmaceutical composition comprising the attenuated bacteria; and the use of the attenuated bacteria for the manufacture of a pharmaceutical composition for the delivery of one or more primary effector molecules for the treatment of a solid tumor cancers.