METHOD AND APPARATUS FOR AUTOMATED SWAB SAMPLE ANALYSIS

摘要

A method for the analysis of cleaning samples is described. These samples, delivered as adsorbates on a wiping surface like swabs, are produced in order to verify the absence of contamination for example in manufacturing equipment, after a specific cleaning procedure. The method is based on the automated extraction of swabs with a general purpose solvent by means of a liquid handler apparatus, the preparation of samples and standards in a well plate format, followed by HPLC/MS analysis of the assay of the active ingredient residues.