PROCESS FOR PRODUCTION OF N-METHACRYLOYL-4-CYANO-3- TRIFLUOROMETHYLANILINE, METHOD FOR STABILIZATION OF THE SAME, AND PROCESS FOR PRODUCTION OF BICALUTAMIDE

摘要

A process for the production of N-methacryloyl-4-cyano -3-trifluoromethylaniline which comprises reacting 4-cyano-3-trifluoromethylaniline with methacrylic acid or a reactive derivative thereof in the presence of a polymerization inhibitor; a process for the production of bicalutamide which comprises reacting 4-cyano-3-trifluoromethylaniline with methacrylic acid or a reactive derivative thereof in the presence of a polymerization inhibitor and reacting the obtained N-methacryloyl-4-cyano-3-trifluoromethylaniline with a peroxycarboxylic acid, 4-fluorothiophenol, and a peroxy- carboxylic acid successively; and a method for the stabilization of N-methacryloyl-4-cyano-3-trifluoromethylaniline which comprises incorporating a polymerization inhibitor into N-methacryloyl-4-cyano-3-trifluoromethylaniline.