发明名称 |
Phenotypic effects of ubiquinone deficiencies and methods of screening thereof |
摘要 |
The present invention relates to a method of screening for a compound allowing survival of clk1 homozygous mutant embryos; a method of screening for a compound suitable for rescue of mutant phenotype of mclk1 homozygous cell line; a method of screening for a compound suitable for partial or complete functional replacement of endogenous ubiquinone; a method for screening a compound capable of inhibiting activity of clk-1 and/or other processes required to make ubiquinone from demethoxyubiquinone; a non-ubiquinone-producer mouse; a DNA construct, which comprises an alteration of mclk1; a non-ubiquinone-producer ES cell line; a coq-3 mutant subject non-ubiquinone producer, a method of screening for a compound suitable for complete or partial functional ubiquinone or demethoxyubiquinone replacement; a method for reducing and/or increasing ubiquinone level in a multicellular subject; a method of screening for a genetic suppressor of clk-1; and a method of screening for a genetic suppressor of coq-3.
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申请公布号 |
US2005039221(A1) |
申请公布日期 |
2005.02.17 |
申请号 |
US20040486309 |
申请日期 |
2004.09.27 |
申请人 |
HEKIMI SIEGFRIED;HIHI ABDELMADJID;LEVAVASSEUR FRANCOISE;SHOUBRIDGE ERIC;GAO YUAN |
发明人 |
HEKIMI SIEGFRIED;HIHI ABDELMADJID;LEVAVASSEUR FRANCOISE;SHOUBRIDGE ERIC;GAO YUAN |
分类号 |
A01K67/027;A01K67/033;A61K49/00;C12N5/10;C12N9/02;C12N9/10;C12N15/09;C12N15/85;C12Q1/02;C12Q1/26;G01N33/50;(IPC1-7):A01K67/027;C12N5/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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