Imidazo[1,2-A]pyridine and pyrazolo[2,3-A]pyridine derivatives

摘要

A compound of formula (I) wherein Ring A is imidazol[1,2a]pyrid-3-yl or pyrazolo[2,3a]pyrid-3-yl; R<2 >is as defined within; m is 0-5; wherein the values of R<2 >may be the same or different; R<1 >is as defined within; n is 0 to 2, wherein the values of R<1 >may be the same or different; Ring B is phenyl or phenyl fused to a C5-7cycloalkyl ring; R<3 >is as defined within; p is 0-4; wherein the values of R<3 >may be the same or different; R<4 >is as defined within; q is 0-2; wherein the values of R<4 >may be the same or different; and wherein p+q<=5; or a pharmaceutically acceptable salt or an in vivo hydrolyzable ester thereof is described. The use of compounds of formula (I) in the inhibition of cell cycle kinases CDK2, CDK4, and CDK6 are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.