| 摘要 |
1305644 #-Adrenolytic medicines BOEHRINGER INGELHEIM GmbH 16 April 1970 [16 April 1969] 18243/70 Heading A5B Pharmaceutical compositions having improved #-adrenolytic activity comprise a #- receptor blocking agent of the 1-aryloxy-2- hydroxy-3-aminopropane or 1-aryl-1-hydroxy- 2-amino-methane type and a "minor tranquilizer". The #-adrenolyties are those of the general formula: Ar-OCH 2 -CHOH-CH 2 - NHR wherein Ar is an iso-, homo- or heterocyclic group which contains at least one 6- membered aromatic ring linked directly to the remainder of the molecule and which may optionally be substituted by one or more C 1-4 alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, alkylnyloxy, alkylthio, alkylsuphonyl, hydroxyalkyl, aminoalkyl, alkylamino, dialkylamino, acyl, acyloxy, acylamino, phenyl, phenoxy, phenylamino, phenylthio, phenylsulphonyl, phenylsulphonylamino, benzoylamino, phenalkoxy, haloalkyl, alkoxyalkyl, monoalkylaminoalkyl or dialkylaminoalkyl, nitro, hydroxy, amino, cyano or halogeno groups and R is a C 1-8 alkyl or hydroxyalkyl groups and those of the general formula: Ar 1 -CHOHCHR 1 ,-NHR wherein Ar 1 is a phenyl, naphthyl, tetralyl or indanyl group optionally substituted by halo, nitro, alkyl or alkoxy groups, R is a C 1-8 alkyl or hydroxyalkyl group and R 1 is hydrogen or a C 1-4 alkyl group. Suitable tranquilizers are those which are non-hypnotic and show no antipsychotic effect and include Hydroxyzine, Methylpentynol, Mephenesin, Mephenesin carbamate, Guiaphenesin, Meprobamate, Prenderol, Carisoprodol, Mebutamate, Chlordiazepoxide, Diazepam. Nitrazepam, Medazepam and Oxazepam. The compositions may be in conventional forms for oral, rectal and parenteral administration. |
