BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS

摘要

Leukotriene A4 hydrolase (LTA4H) inhibitors of formula I, compositions containing them, and their use for the inhibition of LTA4H enzyme activity a nd the treatment, prevention or inhibition of inflammation and/or conditions associated with inflammation, wherein X is selected from the group consistin g of NR5, O, and S, with R5 being one of the H and CH3; Y is selected from the group consisting of CH2 and O; R4 is selected from the group consisting of H , OCH3, Cl, F, Br, I, OH, NH2, CN, CF3.