发明名称 |
ANTIBODIES AND METHODS FOR GENERATING GENETICALLY ALTERED ANTIBODIES WITH ENHANCED EFFECTOR FUNCTION |
摘要 |
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on th e natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interes t to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the effector function of monoclonal antibodies and monoclonal antibodies with increased effector function.
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申请公布号 |
CA2534077(A1) |
申请公布日期 |
2005.02.10 |
申请号 |
CA20042534077 |
申请日期 |
2004.07.29 |
申请人 |
MORPHOTEK, INC. |
发明人 |
NICOLAIDES, NICHOLAS E.;SANDS, HOWARD;SASS, PHILOP M.;GRASSO, LUIGI |
分类号 |
A61K39/395;A61K48/00;C07K16/00;C07K16/42;C12N5/00;C12N5/06;C12N5/16;C12N15/00;C12N15/10 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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