发明名称 |
CROSSLINKED COMPOSITIONS COMPRISING COLLAGEN AND DEMINERALIZED BONE MATRIX |
摘要 |
A composition comprising a collagen protein and demineralized bone matrix is described wherein the composition is chemically cross-linked with a carbodiimide such as N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC). The crosslinking reaction can be conducted in the presence of N-hydroxysuccinimide (NHS). The collagen can be in a porous matr ix or scaffolding. The DBM can be in the form of particles dispersed in the collagen. A method of making the composition is also described wherein a collagen slurry is cast into the desired shape, freeze dried to form a porou s scaffolding and infiltrated with a solution comprising the cross-linking agent. The composition can be used as an implant for tissue (e.g., soft tiss ue or bone) engineering.
|
申请公布号 |
CA2533758(A1) |
申请公布日期 |
2005.02.10 |
申请号 |
CA20042533758 |
申请日期 |
2004.07.22 |
申请人 |
SDGI HOLDINGS, INC. |
发明人 |
MCKAY, WILLIAM F.;TORRIANNI, MARK W.;EVERAERTS, F. J. L.;DRAPEAU, SUSAN J. |
分类号 |
A61L24/00;A61L24/10;A61L27/22;A61L27/36 |
主分类号 |
A61L24/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|