| 摘要 |
An association is disclosed between the elevated levels of the G-protein coupled receptor 54 (GPR54) and certain cell proliferative diseases, such as kidney cancer. The invention further relates to screening methods to identify compounds that interact with the G-protein coupled receptor to identify agonists and antagonists for diagnosis and treatment. The invention also relates to directed targeting using agents that interact with GPR54, (e.g., anti-GPR54 antibodies or peptide agonists) which are coupled to a toxin.
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