| 摘要 |
1,236,842. Substituted 1-alkyl pyrrolidines. SOC. D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE FRANCE. 19 Aug., 1969 [19 Aug., 1968; 20 May, 1969; 9 June, 1969], No. 41382/69. Heading C2C. Novel 1 - alkyl - 2 - nitromethylenepyrrolidines having the formula wherein R 1 is an alkyl group, prepared by reacting a 1-alkyl-2-pyrrolidinone of the formula with a dialkyl sulphate of the formula (R 2 ) 2 SO 4 wherein R 2 is an alkyl group having from 1 to 5 carbon atoms, or a trialkyl oxonium fluoroborate of the formula BF 4 O(R 3 ) 3 wherein R 3 is a straight chain alkyl group having from 1 to 5 carbon atoms, together with an alkali metal alkoxide and nitromethane, are used to prepare 1 - alkyl - 2 - aminomethylpyrrolidines of the formula by reduction with a metal and an acid or by the action of hydrogen in the presence of a metallic hydrogenation catalyst. The 1-alkyl-2-pyrrolidinone starting material may be prepared by hydrogenating 1-vinyl-2-pyrrolidinone in the presence of a metallic hydrogenation catalyst such as platinum black, rhodium on alumina, palladium on carbon and Raney nickel. Triethyloxonium fluoroborate is prepared by reacting boron trifluoride etherate with 1,2- epoxy-3-chloropropane at room temperature and removing any solvent by decantation. |
