发明名称 |
PYRIMIDINE-2, 4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS |
摘要 |
<p>GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.</p> |
申请公布号 |
WO2005007165(A1) |
申请公布日期 |
2005.01.27 |
申请号 |
WO2004US21593 |
申请日期 |
2004.07.06 |
申请人 |
US;US;US;US;US;US;US;US;US |
发明人 |
GUO, ZHIQIANG;CHEN, YONGSHENG;WU, DONGPEI;CHEN, CHEN;WADE, WARREN;DWIGHT, WESLEY, J.;HUANG, CHARLES, Q.;TUCCI, FABIO, C. |
分类号 |
A61K31/513;A61P5/02;C07D239/54;C07D403/12;C07D405/04;(IPC1-7):A61K31/513;C07D401/12 |
主分类号 |
A61K31/513 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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