GLYCOPROTEIN AND PROCESS FOR PRODUCING THE SAME

摘要

Producing (M1) an active glycoprotein with an acidic sugar-chain containing a mannose-6-phosphate at its non-reducing terminal comprises using a yeast, is new. Independent claims are also included for: (1) the glycoproteins produced by (M1), having an acidic sugar-chain containing mannose-6-phosphate at its non-reducing terminal; (2) drug compositions for treating and/or preventing lysosomal diseases containing the glycoproteins; and (3) producing active glycoproteins of formula (I)-(VII) having a high-mannose-type sugar-chain that contains a mannose-6-phosphate at its non-reducing terminal by using yeast. [Image] where P : P(O)(OH)O 2->. ACTIVITY : Nephrotropic; Hemostatic. No biological data given. MECHANISM OF ACTION : None given in source material.