5-SUBSTITUTED QUINAZOLINONE DERIVATIVES

摘要

Compounds which are alpha- 1A/B adrenoceptor antagonists and which are represented by Formula (I), wherein Q is a monocyclic or bicyclic optionally - substituted heterocyclic ring as defined in the Specification; Z is -C(=O)- or- S(=O)2-; R and R' are lower alkyl; R5 is halogen, cyano, hydroxy, -R6, or - OR6; and R6 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclo, or substituted heterocyclo; and pharmaceutically- acceptable salts, hydrates, prodrugs, and isomers thereof.