| 发明名称 |
CIS-9,10-OCTADECENOAMIDASE |
| 摘要 |
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of cis-9,10-octadecenoamidase. Hydrolysis of cis-9,10-octadecenoamide leads to the formation of oleic acid, a compound without soporific activity. Inhibitors of cis-9,10-octadecenoamidase are disclosed to block this activity. |
| 申请公布号 |
EP0833899(B1) |
申请公布日期 |
2005.01.19 |
| 申请号 |
EP19960918507 |
申请日期 |
1996.06.12 |
| 申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
LERNER, RICHARD A.;CRAVATT, BENJAMIN F.;GILULA, NORTON B. |
| 分类号 |
C12N15/00;A61K31/12;A61P43/00;C07C45/45;C07C49/227;C07C57/03;C07C233/09;C07C327/22;C07F9/54;C12N9/80;C12N9/99;C12P7/64 |
主分类号 |
C12N15/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
