Use of beta-endorphin and/or agents with beta-endorphin-like activity in cosmetic and dermotology

摘要

The use of compound(s) (I) selected from beta -endorphin (BE) and mimetics of the action of BE on skin keratinocytes is claimed (a) in cosmetic compositions for improving the barrier function of the skin, the moisturization of the skin and the resistance of skin to internal and/or external stress or (b) for improving the luster of the skin. An independent claim is included for a cosmetic treatment method for improving the barrier function, moisturization and/or resistance to pollution of skin and/or mucosa, involving application of (I). ACTIVITY : Dermatological. MECHANISM OF ACTION : Activator of production of calmodulin-like skin protein (CLSP), loricrin and/or type I transglutaminase by keratinocytes; keratinocyte differentiation and cornification promoter. In tests in Skinethic (RTM) reconstructed skin, addition of Caobromine (RTM; aqueous glycol extract of cocoa bean shells; ED mimetic active agent) to the cultur medium at 0.1% increased the production of CLSP, loricrin and type I transglutaminase over 24 hours to 291%, 268% and 238% respectively of the control values.